Julian König
Principal Investigator
- Project: Project 2.1, Project 2.2
- Research Group
- Address: IMB, Ackermannweg 4, 55128 Mainz
- Phone: +49 (0) 6131-39-21489
"I have already started seeing my projects from an evolutionary perspective."
- Since 2013: Group Leader, Institute of Molecular Biology (IMB), Mainz
- 2008-2013: Postdoctoral Researcher, MRC Laboratory of Molecular Biology, Cambridge
Education:
- 2008: PhD in Biology, Max Planck Institute for Terrestrial Microbiology and Philipp University, Marburg
- 2003: Diploma in Biology, Ludwig Maximilian University, Munich
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Ebersberger S, Hipp C, Mulorz MM*, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy RFX, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M, König J (2023)
FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns Molecular Cell, 83(15):2653-2672.e15 -
Cortés-López M, Schulz L, Enculescu M, Paret C, Spiekermann B, Quesnel-Vallières M, Torres-Diz M, Unic S, Busch A, Orekhova A, Kuban M, Mesitov M, Mulorz MM, Shraim R, Kielisch F, Faber J, Barash Y, Thomas-Tikhonenko A, Zarnack K, König J (2022)
High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance Nature Communications, 13(1) -
Schulz L, Torres-Diz M, Cortés-López M, Hayer KE, Asnani M, Tasian SK, Barash Y, Sotillo E, Zarnack K, König J and Thomas-Tikhonenko A (2021)
Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts Genome Biology, 22:190 -
Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J and Zarnack K (2021)
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning Nucleic Acids Research -
Worpenberg L, Paolantoni C, Longhi S, Mulorz MM, Lence T, Wessels HH, Dassi E, Aiello G, Sutandy FXR, Scheibe M, Edupuganti RR, Busch A, Möckel MM, Vermeulen M, Butter F, König J, Notarangelo M, Ohler U, Dieterich C, Quattrone A, Soldano A and Roignant JY (2021)
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila EMBO Journal, 40:e104975 -
Werner S, Galliot A, Pichot F, Kemmer T, Marchand V, Sednev M V, Lence T, Roignant J-Y, König J, Höbartner C, Motorin Y, Hildebrandt A and Helm M (2020)
NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination. Nucleic Acids Res -
Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K and Eizirik DL (2020)
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells. Life Sci Alliance, 4:e202000825 -
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R and Meister G (2020)
Validation strategies for antibodies targeting modified ribonucleotides RNA, 26:1489–1506 -
Buchbender A, Mutter H, Sutandy FXR, Körtel N, Hänel H, Busch A, Ebersberger S and König J (2020)
Improved library preparation with the new iCLIP2 protocol Methods, 178:33–48 -
König J and Zarnack K (2020)
High-throughput approaches in RNA biology Methods, 178:1–2 -
Enculescu M, Braun S, Thonta Setty S, Busch A, Zarnack K, König J and Legewie S (2020)
Exon Definition Facilitates Reliable Control of Alternative Splicing in the RON Proto-Oncogene Biophys J, 118:2027–2041 -
Dold A, Han H, Liu N, Hildebrandt A, Brüggemann M, Rücklé C, Hänel H, Busch A, Beli P, Zarnack K, König J, Roignant J-Y and Lasko P (2020)
Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation PLOS Genetics, 1:e1008581 -
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant J-Y, Zarnack K, König J and Beli P (2019)
The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation Genome Biology, 1:216 -
Briese M, Haberman N, Sibley CR, Faraway R, Elser AS, Chakrabarti AM, Wang Z, König J, Perera D, Wickramasinghe VO, Venkitaraman AR, Luscombe NM, Saieva L, Pellizzoni L, Smith CWJ, Curk T and Ule J (2019)
A systems view of spliceosomal assembly and branchpoints with iCLIP Nat Struct Mol Biol, 26:930–940