Jan Padeken
Principal Investigator
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- Address: IMB, Ackermannweg 4 (room 01.123), 55128 Mainz
- Phone: +49 (0) 6131-39-28549
“Nature is a constantly fluctuating and adapting network. The science supported by GenEvo allows us to bring a small part of this into our lab.”
- Since 2022: Group Leader, Institute of Molecular Biology (IMB), Mainz
- 2013 - 2022: Postdoctoral researcher, Friedrich Miescher Institute, Basel
Education:
- 2013: PhD in Cell Biology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg
- 2009: Diploma in Biology, Albert-Ludwigs University, Freiburg
- 2006: Vordiploma in Biology, RWTH Aachen University
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Padeken J, Methot SP, Gasser SM (2022)
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance Nat Rev Mol Cell Biol, 23:623-640 -
Delaney CE, Methot SP, Kalck V, Seebacher J, Hess D, Gasser SM, Padeken J (2022)
SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity Nat Struct Mol Biol, 29:85–96 -
Padeken J, Methot S, Zeller P, Delaney CE, Kalck V, Gasser SM (2021)
Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression Genes Dev, 35:82–101 -
Methot SP*, Padeken J*, Brancati G, Zeller P, Delaney CE, Gaidatzis D, Kohler H, van Oudenaarden A, Großhans H, Gasser SM (2021)
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity Nat Cell Biol, 23(11):1163-1175 -
Harr JC, Schmid CD, Muñoz-Jiménez C, Romero-Bueno R, Kalck V, Gonzalez-Sandoval A, Hauer MH, Padeken J, Askjaer P, Mattout A, Gasser SM (2020)
Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model Genes Dev, 34:560–579 -
Mattout A, Gaidatzis D, Padeken J, Schmid CD, Aeschimann F, Kalck V, Gasser SM (2020)
LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay Nat Cell Biol, 22:579–590 -
Padeken J*, Zeller P*, Towbin B, Katic I, Kalck V, Methot SP, Gasser SM (2019)
Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression Genes Dev, 33:436–451 -
Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer P, Gasser SM (2019)
Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei Nature, 569:734–739 -
Delaney CE*, Methot SP*, Guidi M*, Katic I, Gasser SM, Padeken J (2019)
Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65 J Cell Biol, 218:820–838