Miguel Andrade
Contributing Principal Investigator
- Address: iomE, Hanns-Dieter-Hüsch-Weg 15 (Geb. 1578, 00.470/00.474), 55128 Mainz
- Phone: +49-6131-39-21582
- Since 2014: Adjunct Director, Institute of Molecular Biology (IMB), Mainz, Professor, Faculty of Biology, University of Mainz
- 2007-2014: Group Leader, Max Delbrück Center for Molecular Medicine, Berlin
- 2003-2007: Assistant Professor, University of Ottawa
Education:
- 1994: PhD in Biochemistry, Universidad Complutense de Madrid
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Erdozain S, Barrionuevo E, Ripoll L, Mier P, Andrade-Navarro MA (2023)
Protein repeats evolve and emerge in giant viruses Journal of Structural Biology, 215(2):107962 -
Albrecht S, Andreani T, Andrade-Navarro MA, Fontaine JF (2022)
Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation PLOS ONE, 17(7):e0270043–e0270043 -
Pallares Robles A, ten Cate V, Schulz A, Prochaska JH, Rapp S, Koeck T, Panova-Noeva M, Heitmeier S, Spronk H, Espinola-Klein C, Lackner KJ, Münzel T, Andrade-Navarro MA, Konstantinides SV, ten Cate H, Wild PS (2022)
Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis Scientific Reports, 12(9761) -
Cihan M, Andrade-Navarro MA (2022)
Detection of features predictive of microRNA targets by integration of network data PLOS ONE, 17(6):e0269731 -
Mier P, Fontaine JF, Stoldt M, Libbrecht R, Martelli C, Foitzik S, Andrade-Navarro MA (2022)
Annotation and Analysis of 3902 Odorant Receptor Protein Sequences from 21 Insect Species Provide Insights into the Evolution of Odorant Receptor Gene Families in Solitary and Social Insects Genes, 13(5):919 -
Czeh M, Stäble S, Krämer S, Tepe L, Talyan S, Carrelha J, Meng Y, Heitplatz B, Schwabenland M, Milsom MD, Plass C, Prinz M, Schlesner M, Andrade-Navarro MA, Nerlov C, Jacobsen SEW, Lipka DB, Rosenbauer F (2021)
DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease The Journal of Immunology, ji2100624 -
Mier P, Andrade-Navarro MA (2021)
Between Interactions and Aggregates: The PolyQ Balance Genome Biology and Evolution, 13(11) -
Sprang M, Krüger M, Andrade-Navarro MA and Fontaine JF (2021)
Statistical guidelines for quality control of next-generation sequencing techniques Life Science Alliance, 4(11):e202101113 -
More P, Bindila L, Wild P, Andrade-Navarro M, Fontaine JF (2021)
LipiDisease: associate lipids to diseases using literature mining Bioinformatics, btab559 -
Ten Cate V, Koeck T, Prochaska J, Schulz A, Panova-Noeva M, Rapp S, Eggebrecht L, Lenz M, Glunz J, Sauer M, Ewert R, Halank M, Münzel T, Heitmeier S, Andrade-Navarro MA, Lackner KJ, Konstantinides SV, Leineweber K, Wild PS (2021)
A targeted proteomics investigation of the obesity paradox in venous thromboembolism Blood Advances, 5(14):2909-2918. -
Koch I, Andrade-Navarro MA, Schulz MH and Zarnack K (2021)
Bioinformatics in theory and application – highlights of the 36th German Conference on Bioinformatic Biological Chemistry, 402(8):869-870 -
Kamel M, Kastano K, Mier P and Andrade-Navarro MA (2021)
REP2: A Web Server to Detect Common Tandem Repeats in Protein Sequences Journal of Molecular Biology, 433(11):166895 -
More P, Talyan S, Fontaine JF, Muro EM and Andrade-Navarro MA (2021)
DiseaseLinc: Disease Enrichment Analysis of Sets of Differentially Expressed LincRNAs Cells, 10(4):751 -
Mier P and Andrade-Navarro MA (2021)
The Conservation of Low Complexity Regions in Bacterial Proteins Depends on the Pathogenicity of the Strain and Subcellular Location of the Protein Genes, 12(3):451 -
lbrecht S, Sprang M, Andrade-Navarro MA and Fontaine JF (2021)
seqQscorer: automated quality control of next-generation sequencing data using machine learning Genome Biology, 22(1):75 -
Mier P and Andrade-Navarro MA (2021)
Avoided motifs: short amino acid strings missing from protein datasets. Biological Chemistry, Online ahead of print -
Kastano K, Mier P and Andrade-Navarro MA (2021)
The Role of Low Complexity Regions in Protein Interaction Modes: An Illustration in Huntingtin. International Journal of Molecular Sciences, 22(4):1727 -
Ten Cate V, Prochaska JH, Schulz A, Koeck T, Pallares Robles A, Lenz M, Eggebrecht L, Rapp S, Panova-Noeva M, Ghofrani HA, Meyer FJ, Espinola-Klein C, Lackner KJ, Michal M, Schuster AK, Strauch K, Zink AM, Laux V, Heitmeier S, Konstantinides SV, Münzel T, Andrade-Navarro MA, Leineweber K and Wild PS (2021)
Protein expression profiling suggests relevance of non-canonical pathways in isolated pulmonary embolism. Blood, Online ahead of print. -
Paladin L, Bevilacqua M, Errigo S, Piovesan D, Mičetić I, Necci M, Monzon AM, Fabre ML, Lopez JL, Nilsson JF, Rios J, Menna PL, Cabrera M, Buitron MG, Kulik MG, Fernandez-Alberti S, Fornasari MS, Parisi G, Lagares A, Hirsh L, Andrade-Navarro MA, Kajava AV and Tosatto SCE (2021)
RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures Nucleic Acids Research, 49(D1):D452-D457 -
Mier P and Andrade-Navarro MA (2020)
Assessing the low complexity of protein sequences via the low complexity triangle. PLOS One, 15(12):e0239154 -
Lenz M, Schulz A, Koeck T, Rapp S, Nagler M, Sauer M, Eggebrecht L, Ten Cate V, Panova-Noeva M, Prochaska JH, Lackner KJ, Münzel T, Leineweber K, Wild PS and Andrade-Navarro MA (2020)
Missing value imputation in proximity extension assay-based targeted proteomics data. PLoS One, 15:e0243487 -
Andrade-Navarro MA, Mühlenberg K, Spruth EJ, Mah N, González-López A, Andreani T, Russ J, Huska MR, Muro EM, Fontaine JF, Amstislavskiy V, Soldatov A, Nietfeld W, Wanker EE and Priller J (2020)
RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease Frontiers in Neurology, 11:573560 -
Paladin L, Necci M, Piovesan D, Mier P, Andrade-Navarro MA and Tosatto SCE (2020)
A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication Journal of Structural Biology, 2:107608 -
Paladin L, Bevilacqua M, Errigo S, Piovesan D, Mičetić I, Necci M, Monzon AM, Fabre ML, Lopez JL, Nilsson JF, Rios J, Menna PL, Cabrera M, Buitron MG, Kulik MG, Fernandez-Alberti S, Fornasari MS, Parisi G, Lagares A, Hirsh L, Andrade-Navarro MA, Kajava A V and Tosatto SCE (2020)
RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures. Nucleic Acids Res -
Dallago C, Goldberg T, Andrade‐Navarro MA, Alanis‐Lobato G and Rost B (2020)
Visualizing Human Protein‐Protein Interactions and Subcellular Localizations on Cell Images Through CellMap. Curr Protoc Bioinforma, 1 -
Kastano K, Erdős G, Mier P, Alanis-Lobato G, Promponas VJ, Dosztányi Z and Andrade-Navarro MA (2020)
Evolutionary Study of Disorder in Protein Sequences Biomolecules, 10:1413 -
Vagiona A-C, Andrade-Navarro MA, Psomopoulos F and Petrakis S (2020)
Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1 Genes, 10:1129 -
Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, Riechers S-P, Jain S, Coughlin M, Fontaine J-F, Freibaum BD, Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S, Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP, Kirstein J, Andrade-Navarro MA, Sharan R and Wanker EE (2020)
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell Rep, 32:108050 -
Leismann J, Spagnuolo M, Pradhan M, Wacheul L, Vu MA, Musheev M, Mier P, Andrade‐Navarro MA, Graille M, Niehrs C, Lafontaine DL and Roignant J (2020)
The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila EMBO Reports, 7 -
Jarnot P, Ziemska-Legiecka J, Dobson L, Merski M, Mier P, Andrade-Navarro MA, Hancock JM, Dosztányi Z, Paladin L, Necci M, Piovesan D, Tosatto SCE, Promponas VJ, Grynberg M and Gruca A (2020)
PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins. Nucleic Acids Res, 48:W77–W84 -
Urbanek A, Popovic M, Morató A, Estaña A, Elena-Real CA, Mier P, Fournet A, Allemand F, Delbecq S, Andrade-Navarro MA, Cortés J, Sibille N and Bernadó P (2020)
Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins Structure, 7:733-746.e5 -
Mier P, Andrade-Navarro M (2020)
The features of polyglutamine regions depend on their evolutionary stability BMC Evolutionary Biology, 1:59 -
Andreani T, Albrecht S, Fontaine J-F and Andrade-Navarro MA (2020)
Computational identification of cell-specific variable regions in ChIP-seq data Nucleic Acids Res, 9:e53-e53 -
Laidou S, Alanis-Lobato G, Pribyl J, Raskó T, Tichy B, Mikulasek K, Tsagiopoulou M, Oppelt J, Kastrinaki G, Lefaki M, Singh M, Zink A, Chondrogianni N, Psomopoulos F, Prigione A, Ivics Z, Pospisilova S, Skladal P, Izsvák Z, Andrade-Navarro MA and Petrakis S (2020)
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery Redox Biology, 101458 -
Mier P, Elena-Real C, Urbanek A, Bernadó P and Andrade-Navarro MA (2020)
The importance of definitions in the study of polyQ regions: A tale of thresholds, impurities and sequence context Computational and Structural Biotechnology Journal, 306-313 -
Mier P and Andrade-Navarro MA (2020)
MAGA: A Supervised Method to Detect Motifs From Annotated Groups in Alignments Evolutionary Bioinformatics -
Cheng X, Haeberle S, Shytaj IL, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN and Wölfl S (2020)
NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice Communications Biology, 3:10 -
Alanis-Lobato G, Möllmann JS, Schaefer MH and Andrade-Navarro MA (2020)
MIPPIE: the mouse integrated protein–protein interaction reference Database -
Geiß C, Alanis-Lobato G, Andrade-Navarro M and Régnier-Vigouroux A (2019)
Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages Scientific Reports, 1:17908 -
Ibn-Salem J, Andrade-Navarro MA (2019)
7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs BMC Genomics, 1:777 -
Cheng X, Haeberle S, Shytaj IL, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN and Wölfl S (2019)
Assessment of computational methods for the analysis of single-cell ATAC-seq data Genome Biology, 1:241 -
Muro EM, Ibn-Salem J and Andrade-Navarro MA (2019)
The distributions of protein coding genes within chromatin domains in relation to human disease Epigenetics & Chromatin, 1:72 -
Tørresen OK, Star B, Mier P, Andrade-Navarro MA, Bateman A, Jarnot P, Gruca A, Grynberg M, Kajava A V, Promponas VJ, Anisimova M, Jakobsen KS and Linke D (2019)
Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases Nucleic Acids Research, 21:10994-11006 -
Kamel M, Mier P, Tari A and Andrade-Navarro MA (2019)
Repeatability in protein sequences Journal of Structural Biology, 2:86-91 -
More P, Goedtel-Armbrust U, Shah V, Mathaes M, Kindler T, Andrade-Navarro MA and Wojnowski L (2019)
Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Oncotarget, 51:5298-5312 -
Akhtar J, More P, Albrecht S, Marini F, Kaiser W, Kulkarni A, Wojnowski L, Fontaine J-F, Andrade-Navarro MA, Silies M and Berger C (2019)
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay Life Sci Alliance, 2:e201900318 -
Amrani KE, Alanis-Lobato G, Mah N, Kurtz A, Andrade-Navarro MA (2019)
Detection of condition-specific marker genes from RNA-seq data with MGFR PeerJ, 2019(5):e6970 -
Dabiri Y, Gama-Brambila RA, Taškova K, Herold K, Reuter S, Adjaye J, Utikal J, Mrowka R, Wang J, Andrade-Navarro MA, Cheng X (2019)
Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs iScience, 12:168-181 -
Boeddrich A, Babila JT, Wiglenda T, Diez L, Jacob M, Nietfeld W, Huska MR, Haenig C, Groenke N, Buntru A, Blanc E, Meier JC, Vannoni E, Erck C, Friedrich B, Martens H, Neuendorf N, Schnoegl S, Wolfer DP, Loos M, Beule D, Andrade-Navarro MA, Wanker EE (2019)
The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice Cell Chemical Ecology, 26(1):109-120.e7 -
Almeida MV, Andrade-Navarro MA, Ketting RF (2019)
Function and Evolution of Nematode RNAi Pathways Non-Coding RNA, 5(1):8